Cannabinoids for the treatment of lung inflammation.
Cannabis VS Covid-19
The Coronavirus disease, Covid-19, has caused hundreds of thousands of deaths and millions of cases of infection. This lung disease is extremely dangerous for frail individuals (the elderly and people with chronic diseases). The symptoms of coronavirus are different (fevers, dry cough, joint pain, headaches, nausea, fatigue...).
This virus can also attack the lungs and vital organs in people developing more serious forms, causing breathing difficulties and sometimes death.
With an incubation period of about 14 days, Sars-Cov-2, is now spreading rapidly and makes tens of thousands of people sick every day. The race against time is launched by pharmaceutical laboratories to find a vaccine or to discover an effective treatment against this contagious virus.
Research results are promising. One of the research focuses on the effectiveness of cannabinoids against the inflammation of the lungs caused by the coronavirus.
This scientific research, carried out by a group of researchers from the University of Nebraska and the Texas Research Institute, encourages other centres to continue their research on the anti-inflammatory properties of CBD.
• CBD, Cannabinoids, lung inflammation, cytokine IL-6: Some useful notions
ü CBD: The cannabis plant is extremely rich in so-called cannabinoid molecules. These molecules include THC (tetrahydrocannabinol), delta-9-tetrahydrocannabinol and CBD (cannabidiol).
First discovered in the 1940s, the CBD, which is non-psychoactive, is used against many diseases and various health problems (anxiety, diabetes, cardiovascular disease, osteoarthritis, epileptic seizures, anxiety...);
ü Lung Inflammation: The most severe form of Covid-19 is manifested by inflammatory reactions in the lungs. The virus attacks cells in the lung lining and causes acute respiratory distress syndrome (ARDS);
ü Cytokine IL-6: This is the cytokine of the acute phase of lung inflammation.
• Cannabis VS Covid-19 : Details of the scientific research
In the fight against Sars-Cov-2, scientists are extolling the benefits of CBD and treatments based on this molecule extracted from cannabis.
According to published research, acute lung inflammation, the main cause of death, results from an abundance of Cytokine IL-6 in the body. Interleukin-6 (IL-6) binds to cell membranes and activates the production of many proteins, including proteins in the acute phase of lung inflammation.
To treat this problem, it is necessary to find a drug to limit the action of the cytokine IL-6. Several immunosuppressive drugs studied and tested on patients, although effective in cleaning the lungs, have caused undesirable side effects on other organs such as inflammation of the pancreas. All of these studies have led scientists to continue their research to find a treatment that is both safe and effective in overcoming the lung inflammation caused by SarsCov-2.
Recent research has proven that cannabidiol extracted from cannabis, with its anti-inflammatory properties, can cure coronavirus. Contrary to what many people believe, CBD is not a psychotropic drug.
RThat's why scientists are increasingly interested in this molecule.
• How can the CBD defeat Covid-19?
In a scientific publication entitled "Cannabinoids as novel anti-inflammatory drugs" published on the National Library of Medicine, scientists prove that CBD is very effective against lung inflammation.
Consumed in very specific doses, cannabidiol significantly reduces the production of cytokines, thus blocking the mechanism causing lung inflammation and pulmonary fibrosis.
It should be noted that inflammation and pulmonary fibrosis are the main causes of death in people with Covid-19.
But that's not all! CBD is only one molecule extracted from cannabis. THC has also been studied for its anti-inflammatory properties. However, tetrahydrocannabinol is less tolerated and may cause undesirable side effects in some people.
For this reason, research has focused on the study of CBD.
This molecule, administered at a rate of 1.5 grams per day for 14 days, helps reduce lung inflammation caused by the coronavirus Covid-19. Although the exact mechanism involved is not clear at this point, the results are very encouraging.
CBD, with few side effects, also helps to overcome the anxiety of people with coronavirus, thus boosting their immune system (the anxious state inhibits and diminishes the immune defences).
Scientists are now looking for a treatment that is both tranquilizing and anti-inflammatory. This is why CBD could be the active principle of a future Covid-19 treatment.
Another study by researchers from Pathway Research and Swysh, demonstrated the effectiveness of CBD in modulating gene expression, inhibiting ACE2 receptors and decreasing susceptibility to this lung disease.
The studies were conducted at the laboratory level. Researchers hope to find a treatment, not only curative but also preventive, to reduce the risk of lung inflammation in the near future. The benefits of CBD on physical and mental health are numerous.